D'Souza started her acting career with the Balaji Telefilms show Kahe Naa Kahe in 2007 in which she played the role of Kinjal. D'Souza was ranked No. 19 in the Top 50 Sexiest Asian Women List by Eastern Eye in 2013.
Krystle D'souza's Instagram account defies her image of a demure woman and testifies the actors’s love for clothes, bags, shoes and everything pretty. After all the ideal roles she has essayed on television, it might be a pleasant surprise for Krystle’s fans to see her as a diva. Not many know, but this pretty face also found a place in Top 50 Sexiest Asian Women List by Eastern Eye.